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NIHR Signal: The heart failure drug levosimendan doesn’t improve outcomes in adults with severe infections

The National Institute for Health Research (NIHR) regularly publishes Signals. Signals are summaries of recently published research and intended to provide decision makers in health and social care organisations with ..

Author: National Institute for Health Research
Publication Date: 13 December 2016

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

A study comparing the angiotensin receptor–neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such ..

Author: John J.V. McMurray, M.D., Milton Packer, M.D., Akshay S. Desai, M.D., M.P.H., Jianjian Gong, Ph.D., Martin P. Lefkowitz, M.D., Adel R. Rizkala, Pharm.D., Jean L. Rouleau, M.D., Victor C. Shi, M.D., Scott D. Solomon, M.D., Karl Swedberg, M.D., Ph.D., and Michael R. Zile, M.D
Publication Date: 11 September 2014

A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes

Silent myocardial infarction (MI) is a prevalent finding in patients with type 2 diabetes and is associated with significant mortality and morbidity. Late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) ..

Author: Peter P Swoboda et al
Publication Date: 16 September 2001

Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure

Patients with type 2 diabetes mellitus and elevated urinary albumin:creatinine ratio (ACR) have increased risk of heart failure. We hypothesized this was because of cardiac tissue changes rather than silent ..

Author: Peter P Swoboda et al
Publication Date: 17 July 2017

Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes

We aimed to investigate in patients with type 2 diabetes whether aortic stiffness is: (i) associated with glycaemic control, (ii) associated with adverse outcomes and (iii) can be reversed on treatment ..

Author: Peter P Swoboda et al
Publication Date: 05 March 2018